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Heterocyclic Compounds

1-(2-Dimethylaminoethyl)piperazine

CAS: 3644-18-6

Overview

1-(2-Dimethylaminoethyl)piperazine (CAS 3644-18-6 ), also known commercially as TAP, is a bifunctional tertiary amine building block used in pharmaceutical synthesis and specialty chemical manufacturing.

Its dual amine sites make it a reactive intermediate for constructing complex nitrogen-containing scaffolds in drug development pipelines. In pharmaceutical manufacturing, TAP serves as a key intermediate in synthesis.

This is particularly true where piperazine-based structural motifs are required in the final molecule. Biotechnology researchers use it in the preparation of linkers and conjugates for targeted drug delivery systems.

The compound also functions as a polymerization initiator or catalyst in specialty polymer formulations where controlled amine reactivity is required. In research-scale synthesis, it supports the development of libraries.

These heterocyclic compound libraries are used in high-throughput screening programs. 1-(2-Dimethylaminoethyl)piperazine is supplied as a liquid at standard commercial purities, typically ranging from 97% to 99%+.

Material is available in research quantities through to bulk industrial volumes to support both early-stage development and commercial manufacturing. Technical and high-purity grades are the most common.

These are the most commonly sourced specifications in pharmaceutical and biotechnology procurement. The product meets rigorous industrial requirements for consistency and performance in sensitive chemical reactions.

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Physical Properties

Boiling Point94-95 °C @ Press: 8 Torr
Density0.9165 g/cm³ @ Temp: 20 °C
AppearanceClear yellow liquid
ColorColourless
Formliquid
Refractive Indexn 20/D 1.479

Safety & Handling

Danger GHS05 Hazard Statements H314 Causes severe skin burns and eye damage Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P321 Specific treatment (see … on this label). P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29349990
UN Number2735
ADR Class8
Packing GroupIII
Storage Class8A - Combustible corrosive hazardous materials
WGK (Germany)3

Other Names

Tap – 1-methyl-4-(2-dimethylaminoethyl)piperazine | Nn-dimethyl-2-piperazin-1-ylethanamine

Related Products

Chemical Properties

CAS Number
3644-18-6
EC Number
628-996-8
Mol. Weight
157.26
HS Code
29349990

Industries

Documentation