Overview
4-Methylpyridine (CAS 108-89-4 ) is a pyridine-based heterocyclic building block used across pharmaceutical synthesis, agrochemical manufacturing, and specialty chemical production. It functions primarily as a reactive intermediate and catalyst.
In pharmaceuticals, it serves as a key precursor in the synthesis of isonicotinic acid derivatives and active pharmaceutical ingredients targeting cardiovascular and neurological conditions. Agrochemical producers use it to manufacture herbicides.
In coatings and adhesive formulations, it acts as a curing catalyst and crosslinking accelerator for epoxy systems, influencing cure rate and final film performance. It is also known as p-picoline or gamma-picoline.
At trace concentrations, it contributes roasted and nutty flavor notes in food applications, with usage governed by FEMA -recognized flavor standards. This versatility makes it essential for various industrial sectors.
The compound is supplied as a liquid at standard commercial purities, typically 98% and 99%+ grades for pharmaceutical and synthesis applications. Technical-grade material is available for industrial catalyst use.
Packaging ranges from drums to ISO tank quantities depending on volume requirements. Our supply chain ensures consistent quality meeting USP and FCC standards where applicable for specific high-purity industrial needs.
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Physical Properties
| Melting Point | 3.66 °C |
| Boiling Point | 145 °C @ Press: 760 Torr |
| Density | 0.9548 g/cm³ @ Temp: 20 °C |
| Flash Point | 134 °F |
| Appearance | Picolines are colorless liquids. Strong, unpleasant, pyridine-like odor.“Picoline” is often used as mixed isomers. |
| Color | Clear light yellow |
| Odor | Obnoxious, Sweetish |
| Form | Liquid |
| Water Solubility | soluble |
| Vapor Pressure | 4 mm Hg ( 20 °C) |
| Refractive Index | n 20/D 1.504(lit.) |
| Log P | 1.22 at 25℃ |
Safety & Handling
Danger GHS02 GHS06 GHS07 GHS08 Hazard Statements H226 H226 H302 H302 H311 H311 H315 H315 H319 H319 H332 H332 H335 H335 H336 H336 H372 H372 Precautionary Statements P210 P210 P233 P233 P240 P240 P241 P241 P242 P242 P243 P243 P260 P260 P261 P261 P262 P262 P264 P264 P270 P270 P271 P271 P280 P280 P316 P316 P317 P317 P319 P319 P321 P321 P330 P330 P405 P405 P501 P501 P264+P265 P264+P265 P301+P317 P301+P317 P302+P352 P302+P352 P304+P340 P304+P340 P332+P317 P332+P317 P337+P317 P337+P317 P361+P364 P361+P364 P362+P364 P362+P364 P370+P378 P370+P378 P403+P233 P403+P233 P403+P235 P403+P235 P303+P361+P353 P303+P361+P353 P305+P351+P338 P305+P351+P338
Trade & Regulatory
| HS Code | 29333955 |
| UN Number | 1992 |
| ADR Class | 3 |
| Packing Group | III |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 108-89-4
- EC Number
- 203-626-4
- Mol. Weight
- 93.13
- HS Code
- 29333955
- Category
- Heterocyclic Compounds