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Pharmaceutical Intermediates

Vanillic acid

CAS: 121-34-6

Overview

Vanillic acid (CAS 121-34-6 ), also identified by its FEMA number 3988 , is a naturally derived phenolic acid used across pharmaceutical, food, and cosmetic manufacturing.

Commercially recognized as vanillate in salt form, it functions as an antioxidant, preservative, and UV-stabilizing agent in finished formulations. In pharmaceutical manufacturing, it serves as an intermediate.

It contributes antioxidant stabilization to drug formulations sensitive to oxidative degradation. Food and beverage producers incorporate it as a flavoring adjunct and oxidation inhibitor in various products.

Phenolic antioxidants are often preferred over synthetic alternatives in these applications. Cosmetic and personal care formulators use it in skin-care products for its combined antioxidant and UV-stabilizing properties.

It is particularly effective in formulations targeting photoprotection. It also functions as a preservative booster in multi-ingredient systems, extending shelf life without requiring high active concentrations.

Vanillic acid is supplied as a white to off-white crystalline powder. Standard commercial grades include food-grade material meeting FEMA 3988 specifications and pharmaceutical-grade material.

These grades are aligned with USP or technical-grade standards depending on end-use requirements. Packaging is available in kilogram quantities through bulk metric-ton volumes for industrial needs.

This ensures the product suits both development-scale and industrial procurement needs. Our supply chain ensures consistent quality and availability for global manufacturing partners across all sectors.

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Physical Properties

Melting Point211.5 °C
Boiling Point257.07°C (rough estimate)
Density1.44 g/cm³ @ Temp: 25 °C
Appearancewhite odourless crystals or powder
ColorClear colorless to brown, may darken during storage
Odorat 100.00 %. dairy milky custard creamy powdery vanilla bean
FormLiquid
Water SolubilitySoluble in water, alcohol and ether.
Refractive Index1.5090 (estimate)
Log P1.30

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29189090
Storage Class11 - Combustible Solids
WGK (Germany)1

Other Names

Protocatechuic acid3-methyl ether | Vanillate | p-Vanillic acid | p-Vanillate | m-Anisic acid4-hydroxy- | Benzoic acid4-hydroxy-3-methoxy- | Acide vanillique | 4-Hydroxy-m-Anisic acid

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Chemical Properties

CAS Number
121-34-6
EC Number
204-466-8
Mol. Weight
168.15
HS Code
29189090

Industries

Documentation