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Pharmaceutical Intermediates

Vanillin

CAS: 121-33-5

Overview

Vanillin (CAS 121-33-5 ), also sold under the trade name Zimco, is the primary synthetic flavoring compound used to replicate and extend natural vanilla flavor across food, fragrance, and pharmaceutical applications.

Derived from guaiacol or lignin, it delivers a consistent, cost-effective alternative to vanilla bean extract at commercial scale. In food and beverage manufacturing, it is used to flavor chocolate and baked goods.

It is also essential for dairy products and confectionery where natural vanilla economics are prohibitive. Fragrance formulators incorporate it into personal care products including perfumes, lotions, and soaps.

The compound is valued for its warm, sweet base note and fixative effect. Pharmaceutical manufacturers use it as an intermediate in the synthesis of active ingredients, including certain antiviral and cardiovascular compounds.

It also serves as a masking agent in oral dosage forms. In printing inks and coatings, it functions as a UV stabilizer, helping protect various substrates from the effects of photodegradation.

The product is supplied as a white to off-white crystalline powder. Standard commercial grades include food-grade ( FCC ), pharmaceutical-grade ( USP / BP ), and technical-grade for industrial applications.

Packaging typically ranges from 25 kg bags to bulk quantities. Purity specifications are commonly at 99% or higher for regulated applications, ensuring consistency across all manufacturing sectors.

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Physical Properties

Melting Point80-81 °C
Boiling Point284-285 °C @ Press: 760 Torr
Density1.056 g/cm³
Flash Point147 °C
AppearanceWhite, crystalline needles; sweetish smell. Soluble in 125 parts water, in 20 parts glycerol, and in 2 parts 95% alcohol; soluble in chloroform and ether. Combustible.
ColorWhite to pale yellow
Odorat 100.00 %. vanilla
FormCrystalline Powder
Water Solubility10 g/L (25 ºC)
Vapor Pressure>0.01 mm Hg ( 25 °C)
Refractive Index1.4850 (estimate)
pH4.3 (10g/l, H2O, 20℃)
Log P1.17 at 25℃

Safety & Handling

Warning GHS07 GHS09 Hazard Statements H302 Harmful if swallowed H317 May cause an allergic skin reaction H319 Causes serious eye irritation H320 Causes eye irritation H402 Harmful to aquatic life H411 Toxic to aquatic life with long lasting effects H412 Harmful to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P330 Rinse mouth. P391 Collect spillage. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29124100
Storage Class11 - Combustible Solids
WGK (Germany)1

Other Names

Zimco | Vanilline | Vanillin sodium salt | Vanillin [usan] | Vanillin (NF) | Vanillin (natural) | Vanillin (3-methoxy-4-hydroxy- benzaldehyde) | Vanilla oleoresin (vanilla SPP)

Related Products

Chemical Properties

CAS Number
121-33-5
EC Number
204-465-2
Mol. Weight
152.15
HS Code
29124100

Industries

Documentation