Overview
Diethylpropargylamine (CAS 4079-68-9 ), also known as 3-(Diethylamino)propyne, is a tertiary propargylic amine used as a reactive building block and polymerization initiator in specialty chemical synthesis.
Its terminal alkyne group makes it a practical handle for constructing more complex molecular architectures in pharmaceutical and polymer research. In pharmaceutical synthesis, it serves as an intermediate for drug candidates.
This is particularly useful in CNS and enzyme-inhibitor programs. The terminal alkyne functionality supports copper-catalyzed azide-alkyne cycloaddition click chemistry, enabling efficient conjugation steps in medicinal chemistry.
In polymer science, it functions as an initiator or co-monomer for synthesizing stimuli-responsive or functionalized polymers where pendant amine and alkyne groups are both required for the final application.
Biotechnology researchers use it to introduce clickable handles onto biomolecules for labeling, immobilization, or probe development. Diethylpropargylamine is supplied as a liquid for various industrial uses.
It is available primarily at research and development scales, with high-purity grades suited to pharmaceutical intermediate and life sciences applications. Bulk quantities for scale-up synthesis can be sourced easily.
Contact us for supply of Diethylpropargylamine
Physical Properties
| Melting Point | 157-161°C |
| Boiling Point | 120-121 °C |
| Density | 0.8042 g/cm³ @ Temp: 25 °C |
| Flash Point | 156°C |
| Color | Colorless to Light orange to Yellow |
| Form | clear liquid |
| Water Solubility | Soluble in acid. Insoluble in water. |
| Vapor Pressure | 14.6hPa at 20℃ |
| Refractive Index | n 20/D 1.434 |
| Log P | 1.5 at 23℃ |
Safety & Handling
Danger GHS02 GHS05 GHS06 GHS07 Hazard Statements H225 Highly Flammable liquid and vapor H226 Flammable liquid and vapor H302 Harmful if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H315 Causes skin irritation H318 Causes serious eye damage H319 Causes serious eye irritation H331 Toxic if inhaled H412 Harmful to aquatic life with long lasting effects Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29211990 |
| UN Number | 2733 |
| ADR Class | 3 |
| Packing Group | II |
| WGK (Germany) | 3 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 4079-68-9
- EC Number
- 223-804-5
- Mol. Weight
- 111.18
- HS Code
- 29211990
- Category
- Amines