Clopidogrel bisulfate

CAS: 120202-66-6

Overview

Clopidogrel bisulfate (CAS 120202-66-6 ), also marketed under the salt forms clopidogrel hydrogen sulfate, is the active pharmaceutical ingredient form of clopidogrel used in the manufacture of antiplatelet medications.

It is the commercially dominant salt form selected for finished dose production due to its stability profile and processability in solid oral dosage manufacturing. Generic pharmaceutical manufacturers use it as the API in tablet formulations.

These formulations target cardiovascular indications, where precise polymorph control and purity are critical to regulatory submission. Contract development and manufacturing organizations source it as a starting point for 75 mg oral solid dose products.

This dosage represents the most common commercial strength globally. Formulators working on combination cardiovascular products also specify this salt form when developing fixed-dose combinations requiring compatibility with standard tablet excipients.

Clopidogrel bisulfate is supplied as a white to off-white crystalline powder. It is available in pharmaceutical-grade specifications aligned with USP and EP monograph requirements for global compliance.

Polymorph Form I is the standard commercially supplied crystalline form for this material. Packaging typically ranges from small analytical quantities through multi-kilogram lots to support clinical batch manufacturing.

These supply options are designed to facilitate both research and commercial-scale production. The material maintains high stability and purity standards necessary for the rigorous demands of the pharmaceutical industry.

Physical Properties

Melting Point	184 °C
Color	white
Form	solid

Safety & Handling

Danger GHS05 GHS07 GHS09 Hazard Statements H290 May be corrosive to metals H302 Harmful if swallowed H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H332 Harmful if inhaled H335 May cause respiratory irritation H362 May cause harm to breast-fed children H411 Toxic to aquatic life with long lasting effects Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P234 Keep only in original packaging. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P263 Avoid contact during pregnancy and while nursing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P390 Absorb spillage to prevent material damage. P391 Collect spillage. P405 Store locked up. P406 Store in a corrosion-resistant/… container with a resistant inner liner. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29349990
WGK (Germany)	3

Other Names

Industries

Pharmaceuticals & Healthcare