Overview
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (CAS 1892-57-5 ), commonly known as EDC or EDCI, is a water-soluble carbodiimide coupling reagent used to form stable amide and ester bonds.
In industry, it functions as a zero-length crosslinker, activating carboxylic acids for conjugation without becoming part of the final bond. This makes it essential for complex chemical synthesis.
EDC is the reagent of choice for bioconjugation workflows, including antibody-antigen coupling, protein-to-surface immobilization, and diagnostic assay development. It ensures high efficiency in aqueous environments.
In pharmaceutical manufacturing, it supports peptide synthesis and the preparation of drug-protein conjugates where clean, traceable crosslinking chemistry is required for regulatory compliance.
Personal care formulators use it to crosslink hyaluronic acid and other polysaccharides in dermal filler and hydrogel systems. It provides the structural integrity needed for advanced cosmetic applications.
Research-scale and GMP production of biosensors, lateral flow devices, and conjugate vaccines also rely on EDC as a primary activation agent. Its versatility spans across multiple biotech sectors.
EDC is supplied as a white to off-white crystalline powder, with the hydrochloride salt form being the dominant commercial grade due to its superior stability under ambient storage conditions.
It is available in research quantities through to multi-kilogram lots, with pharmaceutical-grade material meeting specifications relevant to GMP bioconjugation processes and industrial standards.
Contact us for supply of 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide
Physical Properties
| Boiling Point | 45 °C @ Press: 1 Torr |
| Density | 0.877 g/mL at 20 °C(lit.) |
| Flash Point | 66-68°C/1mm |
| Color | Colorless to slightly yellow |
| Form | Liquid |
| Water Solubility | Soluble in water. |
| Refractive Index | n 20/D 1.461 |
Safety & Handling
Danger GHS05 GHS06 GHS07 GHS08 GHS09 Hazard Statements H302 Harmful if swallowed H311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H315 Causes skin irritation H317 May cause an allergic skin reaction H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H373 May causes damage to organs through prolonged or repeated exposure H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects Precautionary Statements P233 Keep container tightly closed. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P316 Get emergency medical help immediately. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P363 Wash contaminated clothing before reuse. P391 Collect spillage. P403 Store in a well-ventilated place. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P342+P316 Get emergency medical help immediately. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29252900 |
| UN Number | 2735 |
| ADR Class | 8 |
| Packing Group | III |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| WGK (Germany) | 3 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 1892-57-5
- EC Number
- 217-579-2
- Mol. Weight
- 155.24
- HS Code
- 29252900
- Category
- Heterocyclic Compounds