Overview
Disodium EDTA (CAS 139-33-3 ), also known as Na2H2EDTA and listed as E386 in food applications, is a chelating agent that binds and neutralizes metal ions in formulations and processes.
By sequestering calcium, magnesium, iron, and other trace metals, it prevents discoloration, rancidity, and scale formation across a broad range of industries and finished products.
In personal care and cosmetic formulations, it stabilizes emulsions and preservative systems by removing metal ions that would otherwise accelerate oxidative degradation during the shelf life.
Food manufacturers use it under the E386 designation to protect canned vegetables, dressings, and seafood products from metal-catalyzed color and flavor loss during storage and processing.
Water treatment and industrial cleaning operations rely on it to sequester hardness ions, improving detergent efficiency and preventing mineral deposits in various types of process equipment.
In pharmaceutical manufacturing, it functions as a stabilizer in liquid dosage forms and ophthalmic preparations where trace metal contamination must be tightly controlled for safety.
Disodium EDTA is supplied as a white crystalline powder or granules. Standard grades include food-grade, USP , BP , and Ph. Eur. specifications for pharmaceutical and regulated food applications.
Technical grade is also available for industrial use. Bulk supply is available in bags and fiber drums, with packaging options suited to both formulation-scale and large industrial procurement.
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Physical Properties
| Melting Point | 252 °C (decomp) |
| Boiling Point | >100 °C |
| Density | 1.01 g/mL at 25 °C |
| Appearance | white crystalline solid |
| Color | ≤5 (0.5 M)(APHA) |
| Odor | at 100.00?%. odorless |
| Form | solution |
| Water Solubility | Miscible with water. |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive Index | n20/D 1.363 |
| pH | 8.0±0.2 |
| Log P | -4.3 at 25℃ |
Safety & Handling
Warning GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H373 May causes damage to organs through prolonged or repeated exposure Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29224900 |
| Storage Class | 12 - Non Combustible Liquids |
| WGK (Germany) | 2 |
Other Names
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Chemical Properties
- CAS Number
- 139-33-3
- EC Number
- 205-358-3
- Mol. Weight
- 336.21
- HS Code
- 29224900
- Category
- Salts & Minerals