Overview
Dicyclohexylcarbodiimide (CAS 538-75-0 ), commonly known as DCC, is a coupling reagent used across pharmaceutical synthesis, peptide chemistry, and specialty chemical manufacturing.
It activates carboxylic acids for condensation reactions, enabling the formation of amide, ester, and peptide bonds under mild conditions for various industrial applications.
In pharmaceutical API synthesis, DCC drives amide bond formation in the production of active ingredients where selectivity and yield are critical procurement considerations.
Peptide manufacturers rely on it as a standard coupling agent in both solution-phase and solid-phase peptide synthesis workflows for high-efficiency chemical production.
In flavor and fragrance chemistry, DCC facilitates ester synthesis for aroma compound production where conventional acid-catalyzed routes are unsuitable for the final product.
Cosmetic formulators use it in the synthesis of specialty esters and functional ingredients requiring controlled reaction conditions to ensure the stability of the formulation.
DCC is supplied as a white to off-white crystalline solid. It is available in technical and high-purity reagent grades, with pharmaceutical-grade material meeting specifications.
The material is suitable for GMP synthesis environments. Packaging ranges from laboratory-scale quantities to bulk supply for large-scale industrial synthesis operations.
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Physical Properties
| Melting Point | 34.5 °C |
| Boiling Point | 112 °C @ Press: 3.5 Torr |
| Density | 1.247 g/mL at 25 °C |
| Flash Point | 190 °F |
| Appearance | N,N0 -Dicyclohexylcarbodiimide (DCC) is a white crystalline solid. Odor is sweet and heavy. |
| Color | White to pale yellow |
| Form | Waxy Solid or Crystalline Mass |
| Water Solubility | Reaction |
| Vapor Pressure | 1.044-1.15Pa at 20-25℃ |
| Refractive Index | n 20/D 1.48 |
| Log P | 5.567-6.83 at 25℃ |
Safety & Handling
Danger GHS05 GHS06 GHS07 GHS09 GHS08 Hazard Statements H302 Harmful if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H317 May cause an allergic skin reaction H318 Causes serious eye damage H330 Fatal if inhaled H371 May cause damage to organs H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects H413 May cause long lasting harmful effects to aquatic life Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P320 Specific treatment is urgent (see … on this label). P321 Specific treatment (see … on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29251900 |
| UN Number | 2922 |
| ADR Class | 8 |
| Packing Group | II |
| Storage Class | 6.1D - Non-combustible acute toxic Cat.3 toxic hazardous materials or hazardous materials causing chronic effects |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 538-75-0
- EC Number
- 208-704-1
- Mol. Weight
- 206.33
- HS Code
- 29251900
- Category
- Catalysts & Catalyst Precursors