Overview
N-Ethylisopropylamine (CAS 19961-27-4 ) is a secondary aliphatic amine used as a reactive intermediate and process chemical across pharmaceutical synthesis, agrochemical manufacturing, and polymer chemistry.
It functions primarily as a non-nucleophilic base, pH buffer, and initiator in controlled chemical processes. In pharmaceutical manufacturing, it acts as a base catalyst in multi-step synthesis routes.
This chemical is essential where selectivity is critical and competing nucleophilic reactions must be suppressed. Agrochemical producers use it as a building block in the synthesis of active ingredients.
It is particularly useful where secondary amine functionality is required in the final molecule. In polymer chemistry, it supports polymerization initiation and chain-growth control for specialty resins.
The compound also serves as a carrier solvent and pH-adjusting agent in formulation development. Precise basicity control determines product stability and performance in these industrial applications.
N-Ethylisopropylamine is supplied as a liquid in standard drum and IBC quantities suited to industrial-scale consumption. It is available primarily in technical and reagent grades for various uses.
Purity specifications typically range from 97% to 99% or higher depending on the batch. Buyers should confirm grade suitability against their specific synthesis or formulation requirements before purchase.
Purity tolerance varies significantly between pharmaceutical and industrial applications. Our logistics network ensures reliable delivery of this intermediate to meet your manufacturing timelines and goals.
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Physical Properties
| Melting Point | -75°C (estimate) |
| Boiling Point | 71.1-71.4 °C |
| Density | 0.71 g/cm³ @ Temp: 20 °C |
| Flash Point | 61 °F |
| Appearance | Colorless to light yellow liqui |
| Color | Colorless to Light yellow |
| Form | clear liquid |
| Refractive Index | n 20/D 1.392(lit.) |
Safety & Handling
Danger GHS02 GHS05 Hazard Statements H225 Highly Flammable liquid and vapor H314 Causes severe skin burns and eye damage Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P321 Specific treatment (see … on this label). P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P370+P378 Use … for extinction. P403+P235 Store in a well-ventilated place. Keep cool. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29211990 |
| UN Number | 2733 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 19961-27-4
- EC Number
- 243-442-1
- Mol. Weight
- 87.16
- HS Code
- 29211990
- Category
- Pharmaceutical Intermediates