3-chloro-4-methylaniline

CAS: 95-74-9

Overview

3-Chloro-4-methylaniline (CAS 95-74-9 ), also known as 2-Chloro-4-aminotoluene and abbreviated as 3-CPT, is an aromatic amine intermediate used primarily in the synthesis of agrochemical active ingredients.

It functions as a key building block in the manufacture of herbicides and other crop protection compounds. 3-CPT is most commonly consumed in the production of herbicide active substances.

Its chloro-substituted aniline structure is incorporated into the final molecule during multi-step synthesis. It is used in the manufacture of urea-based and amide-based herbicides targeting broadleaf and grassy weeds.

Formulators and API manufacturers sourcing this intermediate rely on consistent purity to meet the tight specifications required for regulated agrochemical registration dossiers.

It also serves as a precursor in dye and pigment chemistry, though agrochemical synthesis represents the dominant commercial demand. 3-Chloro-4-methylaniline is supplied as a liquid or low-melting solid.

Technical grade is the standard commercial offering, with purity typically specified at 98% or higher by GC. Drum and IBC packaging are conventional for industrial quantities.

Smaller quantities are available for R&D procurement. Handling should be conducted in accordance with safety data sheets due to the characteristic toxicity profile of aromatic amines.

Physical Properties

Melting Point	26 °C
Boiling Point	242-244 °C @ Press: 760 Torr
Density	1.17
Flash Point	212 °F
Appearance	The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.
Color	White or Colorless to Light orange to Yellow
Form	powder to lump to clear liquid
Water Solubility	1 g/L (20 ºC)
Vapor Pressure	4.973-8.666Pa at 25℃
Refractive Index	n 20/D 1.584(lit.)
Log P	2.27

Safety & Handling

Danger GHS06 GHS07 GHS09 Hazard Statements H301 Toxic if swallowed H311 Toxic in contact with skin H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H332 Harmful if inhaled H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P262 Do not get in eyes, on skin, or on clothing. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P330 Rinse mouth. P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P361+P364 Take off immediately all contaminated clothing and wash it before reuse. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29214300
UN Number	2239
ADR Class	6.1
Packing Group	III
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
WGK (Germany)	2

Other Names

Industries

Agriculture & Feed