Overview
L-Hydroxyproline (CAS 51-35-4 ), commonly abbreviated as Hyp, is a non-essential amino acid derived primarily from collagen hydrolysis. It functions as a biochemical marker for collagen content and serves as a building block in peptide synthesis.
In pharmaceutical manufacturing, Hyp is used as a reference standard and synthetic intermediate in the production of collagen-related peptides and drug compounds targeting connective tissue. It is essential for nutraceutical formulations and cosmetic actives development.
Food and nutrition manufacturers incorporate it into collagen-based supplements, functional protein blends, and hydrolyzed collagen products where amino acid profile verification is required. This ensures high-quality standards for consumer health products.
Personal care formulators use it as a moisturizing and stabilizing agent in anti-aging creams, serums, and skin-conditioning treatments where collagen support claims are commercially relevant. It helps maintain the structural integrity of topical applications.
It also serves as an analytical reagent in quality control laboratories for quantifying collagen content in raw materials and finished products. This application is vital for maintaining consistency across various industrial manufacturing processes.
L-Hydroxyproline is supplied as a white crystalline powder. It is available in USP , FCC , and reagent-grade specifications to meet the sourcing requirements of pharmaceutical, food, and cosmetic manufacturers.
Bulk quantities are standard for industrial buyers, with smaller quantities available for R&D and QC applications. Our supply chain ensures that all technical requirements and quality benchmarks are met for every shipment.
Contact us for supply of L-hydroxyproline
Physical Properties
| Melting Point | 274 °C |
| Boiling Point | 242.42°C (rough estimate) |
| Density | 1.478 g/cm³ |
| Appearance | White crystalline powder |
| Color | White |
| Odor | Odorless |
| Form | Crystals or Crystalline Powder |
| Water Solubility | 357.8 g/L (20 º C) |
| Refractive Index | -75.5 ° (C=4, H2O) |
| pH | 5.5-6.5 (50g/l, H2O, 20℃) |
| Log P | -0.350 (est) |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29339990 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 51-35-4
- EC Number
- 200-091-9
- Mol. Weight
- 131.13
- HS Code
- 29339990
- Category
- Amino Acids & Peptides