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Salts & Minerals

Histidine monohydrochloride monohydrate

CAS: 5934-29-2

Overview

Histidine monohydrochloride monohydrate (CAS 5934-29-2 ), also supplied as L-histidine hydrochloride, is the stabilized salt form of the essential amino acid L-histidine. Its hydrated, water-soluble structure makes it the preferred form for buffering and stabilizing sensitive formulations.

This compound is essential for buffering across pharmaceutical, nutritional, and cosmetic manufacturing. In biopharmaceutical manufacturing, it functions as a primary buffer component in monoclonal antibody and protein drug formulations.

Precise pH control directly impacts product stability and shelf life in these applications. Parenteral and injectable drug products rely on this grade to maintain formulation integrity during freeze-drying and long-term storage.

In food and nutritional supplement production, it is used as an amino acid fortifier in clinical nutrition products. It is also a key ingredient in infant formula and sports nutrition blends to ensure proper amino acid profiles.

Cosmetic formulators incorporate it into skin care products for its moisture-retention and antioxidant-stabilizing properties. It is particularly effective in serums and treatment creams targeting sensitive skin types.

Histidine monohydrochloride monohydrate is available as a white crystalline powder. It is commonly supplied in USP , BP , and Ph. Eur. grades to meet pharmaceutical manufacturing requirements.

Food-grade specifications are also available for nutritional applications. Bulk quantities are typically offered in fiber drums or double-lined polyethylene bags to ensure product safety and stability during transport.

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Physical Properties

Melting Point254 °C (decomp)
Density1.49 g/cm3
AppearanceWhite crystals or crystalline powder
ColorWhite
Odorodorless
FormSolid
Water Solubility169.9 g/L (20 ºC)
Vapor Pressure<1 hPa (20 °C)
pH3.5-4.5 (100g/l, H2O, 20℃)
Log P-3.32 at 25℃

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29332990
WGK (Germany)3

Other Names

L-histidine hydrochloride | L-histidine monohydrochloride monohydrate | (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acidhydratehydrochloride | L-histidine hydrochloride monohydrate

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Chemical Properties

CAS Number
5934-29-2
EC Number
611-821-4
Mol. Weight
209.63
HS Code
29332990

Industries

Documentation