Overview
Glycine hydrochloride (CAS 6000-43-7 ), also known as aminoacetic acid hydrochloride, is the hydrochloride salt form of glycine used across pharmaceutical, food, and personal care manufacturing.
It functions primarily as a pH buffer and acidulant in formulations where precise, stable acidic conditions are required. In pharmaceutical manufacturing, it serves as a buffering agent in parenteral formulations.
This material is essential for lyophilized drug products and API synthesis where controlled pH is critical to product stability. Food and nutrition producers use it to adjust acidity in functional food systems.
It also acts as a preservation aid where mild antimicrobial activity is needed at low pH. Personal care formulators incorporate it into skin-conditioning products to support moisture retention.
Its hygroscopic character is beneficial in both leave-on and rinse-off formats. It also appears in peptide synthesis workflows as a protected amino acid precursor for specialty chemical and biotech procurement.
The product is supplied as a white crystalline powder. Pharmaceutical-grade material is available to USP and BP specifications, supporting regulated drug product manufacturing requirements.
Technical and reagent grades are also commercially available for industrial synthesis and laboratory applications. This ensures versatility across various industrial sectors and research environments globally.
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Physical Properties
| Melting Point | 184-185 °C |
| Density | 1.457[at 20℃] |
| Appearance | white crystals or crystalline powder |
| Color | White to almost white |
| Form | Crystalline Powder |
| Water Solubility | SLIGHTLY SOLUBLE |
| Vapor Pressure | 0.003Pa at 20℃ |
| Log P | -3.25 at 20℃ |
Safety & Handling
Danger GHS05 GHS07 Hazard Statements H314 Causes severe skin burns and eye damage H315 Causes skin irritation H318 Causes serious eye damage H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29224999 |
| UN Number | 1789 |
| ADR Class | 8 |
| Packing Group | III |
| WGK (Germany) | 2 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 6000-43-7
- EC Number
- 227-841-8
- Mol. Weight
- 111.53
- HS Code
- 29224999
- Category
- Salts & Minerals