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Heterocyclic Compounds

Quinine hydrochloride dihydrate

CAS: 6119-47-7

Overview

Quinine hydrochloride dihydrate (CAS 6119-47-7 ), commonly referenced as Quinine HCl Dihydrate in pharmaceutical procurement, is the water-soluble hydrochloride salt form of quinine supplied in its stable dihydrate state.

It functions as an antimalarial active and bitter-tasting agent across pharmaceutical and personal care manufacturing. In pharmaceutical manufacturing, it serves as an active pharmaceutical ingredient in antimalarial formulations.

Its hydrochloride salt form offers improved aqueous solubility over quinine sulfate for injectable and oral dosage development. Beverage and flavoring applications utilize its intensely bitter profile to standardize bitterness.

It is used in tonic formulations and reference standards. In personal care and cosmetic formulations, it is incorporated into scalp treatments and hair care products targeting hair loss and scalp conditioning.

QA and analytical laboratories source it as a reference standard for UV fluorescence calibration and spectrophotometric method validation. Quinine hydrochloride dihydrate is available as a white to off-white crystalline powder.

It is supplied in pharmaceutical-grade specifications aligned with BP and Ph. Eur. monographs, supporting GMP-compliant manufacturing environments. Packaging ranges from small quantities to bulk quantities.

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Physical Properties

Melting Point123 °C (approx)
Flash Point122 °C
Appearancewhite to light yellow crystal powde
ColorWhite to off-white
Odorodorless
FormCrystalline Powder or Silky Needles
Water SolubilitySparingly soluble in water.(0.26 g/L) (25°C),
Refractive Index-250 ° (C=2, EtOH)
pH6.0 (10g/l, H2O, 20℃)

Safety & Handling

Warning GHS07 GHS08 Hazard Statements H302 H302 H317 H317 H332 H332 H334 H334 Precautionary Statements P233 P233 P260 P260 P261 P261 P264 P264 P270 P270 P271 P271 P272 P272 P280 P280 P284 P284 P317 P317 P321 P321 P330 P330 P403 P403 P501 P501 P301+P317 P301+P317 P302+P352 P302+P352 P304+P340 P304+P340 P333+P317 P333+P317 P342+P316 P342+P316 P362+P364 P362+P364

Trade & Regulatory

HS Code29334900
Storage Class11 - Combustible Solids
WGK (Germany)3

Other Names

Quinine HCl Dihydrate | Cinchonan-9-ol6'-methoxy-monohydrochloridedihydrate(8a9R)- | Quinidine Hydrochloride Dihydrate | Cinchonan-9-ol6′-methoxy-hydrochloridehydrate (1:1:2)(8α9R)- | Cinchonan-9-ol6′-methoxy-monohydrochloridedihydrate(8α9R)-

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Chemical Properties

CAS Number
6119-47-7
EC Number
205-001-1
Mol. Weight
396.9
HS Code
29334900

Industries

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