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Heterocyclic Compounds

Cinchonine

CAS: 118-10-5

Overview

Cinchonine (CAS 118-10-5 ) is a natural cinchona bark alkaloid used across pharmaceutical, biotechnology, and personal care sectors. Commercially recognized as D-Cinchonine, it functions primarily as a chiral resolving agent.

It serves as a biochemical tool compound in synthesis and research workflows. In pharmaceutical manufacturing, it resolves racemic mixtures to isolate enantiomerically pure active ingredients for production.

This is a critical step in API production where chiral purity directly affects regulatory approval. Biotechnology researchers use it as a reference standard and chiral selector in chromatographic method development.

Personal care formulators incorporate it into preservation systems where alkaloid-based antimicrobial activity supports product stability. It also serves research applications in asymmetric catalysis for development.

Its quinuclidine-quinoline scaffold is used to develop organocatalyst systems. The material is supplied as a white to off-white crystalline powder available in reagent-grade and high-purity specifications.

It is suited to pharmaceutical and analytical applications, with select suppliers offering material compliant with reference standard requirements. Packaging ranges from small research quantities to bulk orders.

Industrial-scale chiral resolution processes utilize this compound for its reliable performance. The product meets rigorous industry expectations for consistency and chemical stability in various environments.

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Physical Properties

Melting Point265 °C
Boiling Point436.16°C (rough estimate)
Density1.0863 (rough estimate)
Appearancewhite to light yellow crystal powde
ColorWhite to light beige
FormMicro-Crystalline Powder
Water SolubilityInsoluble
Vapor Pressure0Pa at 25℃
Refractive Index223 ° (C=0.5, EtOH)
pH9.0 (0.25g/l, H2O, 20℃)(as aqueous solution)
Log P2.82 at 25℃

Safety & Handling

Warning GHS07 Hazard Statements H302 H302 H317 H317 H332 H332 Precautionary Statements P261 P261 P264 P264 P270 P270 P271 P271 P272 P272 P280 P280 P317 P317 P321 P321 P330 P330 P501 P501 P301+P317 P301+P317 P302+P352 P302+P352 P304+P340 P304+P340 P333+P317 P333+P317 P362+P364 P362+P364

Trade & Regulatory

HS Code29339900
WGK (Germany)3

Other Names

D-Cinchonine | (9S)-Cinchonan-9-ol | Cinchonan-9-ol(9S)- | (8R9S)-Cinchonine | (+)-Cinconine | V43X79NZCD | Cinchonine Alkaloid

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Chemical Properties

CAS Number
118-10-5
EC Number
204-234-6
Mol. Weight
294.4
HS Code
29339900

Industries

Documentation