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Organic Acids

5-aminosalicylic acid

CAS: 89-57-6

Overview

5-Aminosalicylic acid (CAS 89-57-6 ) is an aminosalicylate compound used as an active pharmaceutical ingredient and synthesis intermediate across pharmaceutical and personal care manufacturing.

In finished drug products, it functions as the primary therapeutic agent in inflammatory bowel disease formulations. In cosmetic applications, it is evaluated for UV-stabilizing and preservation activity.

The primary commercial demand for 5-ASA is as the active ingredient in mesalazine-branded oral and rectal pharmaceutical formulations, including delayed-release tablets, suppositories, and enemas.

Contract manufacturers and formulators also source it as a key intermediate in the synthesis of azo-linked prodrugs such as sulfasalazine and olsalazine for various medical applications.

In personal care, it is incorporated into formulations targeting UV protection and antimicrobial preservation, particularly where multifunctional actives are preferred by chemical buyers.

Specialty chemical buyers additionally source 5-ASA as a building block for dye intermediates and fine chemical synthesis. It is supplied as a fine off-white to pale yellow powder.

Pharmaceutical-grade material is available to USP , BP , and Ph. Eur. specifications, which are the standard requirements for API procurement in the industry.

Technical-grade material is also available for industrial synthesis applications. These standards ensure the highest level of purity and consistency for global manufacturing partners.

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Physical Properties

Melting Point283 °C
Boiling Point276.03°C (rough estimate)
Density1.5 g/cm³
Flash Point279-281°C
AppearanceOff-White Crystals
Coloroff-white to gray
Formtablets
Water Solubility<0.1 g/100 mL at 21 ºC
Vapor Pressure0Pa at 25℃
Refractive Index1.5500 (estimate)
pH4.0-4.1 (0.8g/l, H2O, 20℃)
Log P0.98 at 25℃

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H335 May cause respiratory irritation H412 Harmful to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29225000
WGK (Germany)2

Other Names

Pentasa® | p-Aminosalicylsaeure | Mésalazine | m-Aminosalicylic acid | 3-carboxy-4-hydroxyaniline | 5-ASA | 5-Aminosalicylate | 5-Amino-2-hydroxybenzoic acid

Related Products

Chemical Properties

CAS Number
89-57-6
EC Number
201-919-1
Mol. Weight
153.14
HS Code
29225000

Industries

Documentation