Synephrine

CAS: 94-07-5

Overview

Synephrine (CAS 94-07-5 ), also known as p-synephrine, is a naturally occurring alkaloid extracted primarily from bitter orange. It functions as an adrenergic agonist active ingredient in pharmaceutical formulations.

The compound is used across nutraceutical and cosmetic applications as a bioactive compound. In pharmaceutical manufacturing, it serves as an active ingredient in preparations targeting nasal congestion and circulatory support.

Its adrenergic activity drives formulation decisions for various medical applications. Nutraceutical producers incorporate it into weight management and sports nutrition products as a stimulant-adjacent botanical extract.

This application is particularly common following restrictions on ephedrine-based ingredients. In topical cosmetic formulations, it is used for its skin-firming and anti-cellulite positioning in slimming creams.

Contract manufacturers also source it as a pharmaceutical intermediate for synthesizing structurally related adrenergic compounds. Synephrine is supplied as a white to off-white crystalline powder.

Standard commercial grades include pharmaceutical-grade material meeting USP or BP specifications. Technical-grade material is also available for industrial synthesis and chemical processing.

High-purity extracts standardized from Citrus aurantium are available for nutraceutical and dietary supplement applications. These extracts ensure consistent potency and quality for global manufacturing standards.

Physical Properties

Melting Point	184.5 °C
Boiling Point	341.1 °C @ Press: 760 Torr
Density	1.1222 (rough estimate)
Appearance	Off-White to Beige Powder
Color	White to Off-White
Form	neat
Refractive Index	1.4680 (estimate)
Log P	-0.450

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code	29225000
WGK (Germany)	3

Other Names

Industries

Pharmaceuticals & Healthcare Personal Care & Cosmetics