Overview
L-5-Hydroxytryptophan (CAS 4350-09-8 ), commonly known as 5-HTP and commercially sourced as Oxitriptan or Griffonia Seed Extract, is a naturally occurring amino acid precursor used across pharmaceutical, nutraceutical, and functional food manufacturing.
It is commercially extracted from the seeds of Griffonia simplicifolia and serves as a direct biosynthetic precursor to serotonin, making it a primary active ingredient in mood and sleep support formulations.
In nutraceutical manufacturing, 5-HTP is the core active in dietary supplement capsules and tablets targeting sleep quality, appetite regulation, and mood balance. Functional food and beverage formulators incorporate it into fortified products.
Pharmaceutical-grade material is used in clinical and OTC product development, particularly in markets where Oxitriptan is recognized as an established API. It meets rigorous quality standards for global distribution.
Cosmetic formulators have adopted it in premium skincare lines for its antioxidant activity, positioning it in anti-aging serums and moisturizing treatments. This versatility makes it a valuable raw material for diverse industries.
5-HTP is supplied as a fine white to off-white powder. Standard commercial grades include food-grade and pharmaceutical-grade specifications, with purity levels typically at 98% or higher by HPLC analysis.
Material derived from Griffonia seed extract is the dominant commercial form and is available with supporting documentation for botanical traceability. Our supply chain ensures consistent quality and reliable lead times for bulk orders.
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Physical Properties
| Melting Point | 273 °C (decomp) |
| Boiling Point | 361.16°C (rough estimate) |
| Density | 0.902 g/mL at 25 °C(lit.) |
| Flash Point | 175 °F |
| Appearance | white to pale grey powder |
| Color | white |
| Form | solid |
| Water Solubility | Slightly soluble |
| Refractive Index | n 20/D 1.4850(lit.) |
| Log P | -0.140 (est) |
Safety & Handling
Danger GHS06 GHS07 Hazard Statements H301 Toxic if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29339990 |
| UN Number | 2811 |
| ADR Class | 6.1 |
| Packing Group | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 4350-09-8
- EC Number
- 224-411-1
- Mol. Weight
- 220.22
- HS Code
- 29339990
- Category
- Amino Acids & Peptides