Overview
5-Hydroxytryptophan (CAS 56-69-9 ), commercially known as 5-HTP, is a naturally occurring amino acid intermediate derived primarily from the seeds of Griffonia simplicifolia. In dietary supplement and nutraceutical manufacturing, it functions as a direct precursor to serotonin.
This makes it a target active ingredient for mood, sleep, and appetite-related formulations. Supplement manufacturers use 5-HTP as the primary active in capsule, tablet, and softgel formats targeting sleep support and stress management.
It is also utilized in weight management categories. In functional food and beverage development, it is incorporated into products where serotonin-pathway support is the intended positioning for the final consumer product.
Cosmetic and personal care formulators apply it in anti-aging and skin-tone products. Its antioxidant activity supports formulation stability and skin conditioning claims across various topical applications and beauty-from-within solutions.
Pharmaceutical-grade material is used in clinical research and as a reference standard in analytical method development. 5-HTP is supplied as a fine white to off-white powder with high solubility characteristics for diverse manufacturing needs.
It is available in food-grade and pharmaceutical-grade specifications, with purity levels typically at 98% or higher confirmed by HPLC. Packaging ranges from small research quantities to bulk commercial volumes for global distribution.
Material is commonly sourced to USP or BP -aligned quality standards to ensure safety and efficacy. Our supply chain ensures consistent potency and rigorous testing for heavy metals and microbiological contaminants in every batch.
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Physical Properties
| Melting Point | 298 °C (decomp) |
| Boiling Point | 361.16°C (rough estimate) |
| Density | 1.484 |
| Color | Off-White to Pale Beige |
| Form | solid |
| Water Solubility | Soluble in water (4 mg/ml at 25°C), methanol. |
| Refractive Index | 1.5200 (estimate) |
| Log P | -0.292 (est) |
Safety & Handling
Danger GHS02 GHS06 GHS07 Hazard Statements H226 Flammable liquid and vapor H301 Toxic if swallowed H302 Harmful if swallowed H319 Causes serious eye irritation H332 Harmful if inhaled Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P301+P317 Get emergency medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P370+P378 Use … for extinction. P403+P235 Store in a well-ventilated place. Keep cool. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 56-69-9
- EC Number
- 200-284-8
- Mol. Weight
- 220.22
- Category
- Amino Acids & Peptides