Overview
Isophthaloyl chloride (CAS 99-63-8 ), also known as IPC or m-phthaloyl chloride, is a reactive diacid chloride monomer used to build high-performance polymer chains through acylation reactions.
It functions as a key building block in the synthesis of aramids, polyamides, and polyesters where thermal stability and mechanical strength are required end targets for the final material.
In aramid fiber production, IPC reacts with aromatic diamines to form meta-aramid polymers. These are the basis of heat-resistant textiles used in protective apparel and industrial filtration systems.
Polyamide and polyester resin manufacturers use it to introduce isophthalate units that improve flexibility and chemical resistance. This enhances long-term durability in various engineering plastics.
In coatings and adhesives, IPC serves as a cross-linking agent that builds dense polymer networks. These networks are essential for high-temperature or chemically aggressive service environments.
Pharmaceutical manufacturers use it as an acylating intermediate in the synthesis of active ingredients. It is also utilized in the creation of specialty amide-bond-containing compounds.
Isophthaloyl chloride is supplied as a white to off-white crystalline solid. Standard commercial grades are available for industrial and synthesis-scale applications across many sectors.
High-purity grades are offered to meet pharmaceutical and fine chemical manufacturing requirements. Packaging ranges from small quantities for laboratory use to bulk volumes for polymer production.
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Physical Properties
| Melting Point | 43-44 °C |
| Boiling Point | 276 °C |
| Density | 1.3880 g/cm³ @ Temp: 17 °C |
| Flash Point | 356 °F |
| Appearance | white crystalline mass |
| Color | White |
| Form | Crystalline Mass |
| Water Solubility | reacts |
| Vapor Pressure | 0.03 mm Hg ( 25 °C) |
| Refractive Index | 1.5700 (estimate) |
Safety & Handling
Danger GHS05 GHS06 GHS07 Hazard Statements H312 Harmful in contact with skin H314 Causes severe skin burns and eye damage H318 Causes serious eye damage H331 Toxic if inhaled Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P316 Get emergency medical help immediately. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P363 Wash contaminated clothing before reuse. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P301+P330+P331 Rinse mouth. Do NOT induce vomiting. P302+P361+P354 IF ON SKIN: Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29173940 |
| UN Number | 3261 |
| ADR Class | 8 |
| Packing Group | II |
| Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2 very toxic hazardous materials |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 99-63-8
- EC Number
- 202-774-7
- Mol. Weight
- 203.02
- HS Code
- 29173940
- Category
- Organic Acids