Overview
4-Bromophenyl isocyanate (CAS 2493-02-9 ), also known as p-bromophenyl isocyanate, is a reactive aryl isocyanate used as a building block in organic synthesis and polymer chemistry.
The bromine substituent provides a handle for further functionalization, making it a practical intermediate for constructing complex molecular architectures in pharmaceutical and specialty chemical workflows.
In pharmaceutical synthesis, it serves as a key intermediate for preparing urea-containing drug candidates and bioactive compounds where the bromine atom enables downstream cross-coupling reactions.
Agrochemical and fine chemical manufacturers use it to introduce the bromophenyl-urea motif into active ingredient scaffolds. In polymer research, it functions as a monomer for producing specialty polyureas.
Biotechnology researchers also employ it in the preparation of labeled probes and derivatization reagents for analytical applications. It is supplied as a liquid or low-melting solid in high-purity grades.
Standard offerings include reagent-grade and synthesis-grade material, with purity specifications commonly at 97% or higher by GC. Packaging ranges from small quantities to bulk quantities for industrial use.
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Physical Properties
| Melting Point | 134 °C |
| Boiling Point | 78-80 °C @ Press: 5 Torr |
| Density | 1.6077 (rough estimate) |
| Flash Point | 229 °F |
| Appearance | WHITE TO LIGHT BEIGE CRYSTALLINE SOLID |
| Color | White to light beige |
| Form | Crystalline Solid |
| Water Solubility | Sparingly soluble in water (0.40 g/L at 25°C). |
| Refractive Index | 1.5500 (estimate) |
Safety & Handling
Danger GHS07 GHS08 Hazard Statements H312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 May cause respiratory irritation Precautionary Statements P233 Keep container tightly closed. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P403 Store in a well-ventilated place. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P342+P316 Get emergency medical help immediately. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29291090 |
| WGK (Germany) | 3 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 2493-02-9
- EC Number
- 219-662-9
- Mol. Weight
- 198.02
- HS Code
- 29291090
- Category
- Monomers & Building Blocks