Overview
Diethyl malonate (CAS 105-53-3 ), also known by the abbreviation DEM or as malonic ester, is a diester compound used as a synthetic intermediate and flavoring agent across food, fragrance, and specialty chemical manufacturing.
Its reactivity at the active methylene group makes it a foundational building block for producing pharmaceuticals, agrochemicals, and aroma compounds at industrial scale. In flavor and fragrance production, DEM functions as a precursor to fruity aroma compounds.
The material carries FEMA 2375 status for direct use as a flavoring ingredient. Agrochemical manufacturers rely on it as a key intermediate in synthesizing active ingredients including certain herbicides and insecticides.
In pharmaceutical synthesis, it serves as a carbon-chain extender in the production of barbiturates, amino acids, and other active pharmaceutical ingredients. Personal care formulators use it as a carrier solvent and reactive intermediate.
Diethyl malonate is supplied as a clear liquid in drum and IBC quantities, with bulk tanker options available for high-volume buyers. Standard commercial grades include technical and food-grade ( FCC ) specifications.
Purity levels of 99% and above are typical for synthesis-grade material supplied to pharmaceutical and agrochemical customers. Our logistics network ensures reliable delivery of high-purity esters for diverse industrial applications.
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Physical Properties
| Melting Point | -50 °C |
| Boiling Point | 199 °C |
| Density | 1.017336 g/cm³ @ Temp: 55.00 °C |
| Flash Point | 212 °F |
| Appearance | colourless liquid |
| Color | colourless liquid |
| Odor | Sweet ester odor |
| Form | Liquid |
| Water Solubility | Miscible with ethyl alcohol, ether, chloroform and benzene. Slightly miscible with water. |
| Vapor Pressure | 1 mm Hg ( 40 °C) |
| Refractive Index | n 20/D 1.413(lit.) |
| Log P | 0.96 at 20℃ |
Safety & Handling
Warning GHS07 Hazard Statements H227 Combustible liquid H319 Causes serious eye irritation H402 Harmful to aquatic life Precautionary Statements P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P403 Store in a well-ventilated place. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P370+P378 Use … for extinction. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29171910 |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 105-53-3
- EC Number
- 203-305-9
- Mol. Weight
- 160.17
- HS Code
- 29171910
- Category
- Organic Acids