Overview
Celecoxib (CAS 169590-42-5 ), also marketed under the brand name Onsenal®, is a selective COX-2 inhibitor API used as the active pharmaceutical ingredient in prescription anti-inflammatory drug products.
It is sourced by pharmaceutical manufacturers and contract formulators for finished dosage form production. Celecoxib is the primary active ingredient in oral solid dosage forms, principally hard gelatin capsules.
These products are indicated for arthritis and acute pain management. Contract manufacturers source it for inclusion in both branded and generic pharmaceutical products across regulated markets globally.
Its low aqueous solubility drives demand for specialized formulation approaches, including solid dispersions and nanoparticle-based systems. This makes it a reference compound in bioavailability enhancement development.
API suppliers also serve research institutions and analytical laboratories requiring reference-grade material for method validation and comparative studies. Celecoxib is supplied as a white to off-white crystalline powder.
It is available in pharmaceutical-grade specifications conforming to USP and EP monograph standards. Documentation packages include CoA, DMF references, and ICH-compliant impurity profiles.
Bulk quantities are typically offered for commercial manufacturing, with smaller quantities available for R&D and formulation development purposes. This ensures supply chain flexibility for various scales.
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Physical Properties
| Melting Point | 157-159 °C |
| Boiling Point | 529.0±60.0 °C(Predicted) |
| Density | 1.549 g/cm³ (solid) |
| Appearance | White to Pale Yellow Solid |
| Color | white to off-white |
| Form | powder |
| Water Solubility | 7mg/L(25 ºC) |
Safety & Handling
Danger GHS07 GHS08 GHS09 Hazard Statements H317 May cause an allergic skin reaction H319 Causes serious eye irritation H360 May damage fertility or the unborn child H401 Toxic to aquatic life H411 Toxic to aquatic life with long lasting effects Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P318 IF exposed or concerned, get medical advice. P321 Specific treatment (see … on this label). P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29350090 |
| UN Number | 3077 |
| ADR Class | 9 |
| Packing Group | III |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 169590-42-5
- EC Number
- 685-962-5
- Mol. Weight
- 381.4
- HS Code
- 29350090
- Category
- Pharmaceutical Intermediates