Overview
Ethacridine lactate (CAS 1837-57-6 ), commercially recognized as Rivanol and Acrinol, is an antiseptic acridine derivative used in pharmaceutical and healthcare manufacturing. It functions as a topical antimicrobial and preservative active.
The compound has established use in wound care and gynecological preparations. In topical pharmaceutical formulations, it is incorporated into wound-cleansing solutions, antiseptic creams, and gauze dressings targeting bacterial contamination.
These applications focus on minor wounds and ulcers. Gynecological applications include its use in vaginal antiseptic preparations and, in some markets, as an active in labor-induction protocols under clinical supervision.
As a preservative active in pharmaceutical manufacturing, it provides antimicrobial protection in aqueous formulations where conventional preservatives are unsuitable. This makes it a versatile component for specialized medicine.
Contract manufacturers and compounding pharmacies sourcing for Eastern European, Asian, and Latin American markets represent a significant procurement base. Rivanol-branded products retain a strong market presence in these regions.
Ethacridine lactate is supplied as a yellow crystalline powder. Pharmaceutical-grade material is available to BP and Ph. Eur. specifications, with technical-grade material offered for non-medicinal applications.
Buyers typically source in kilogram quantities for formulation development, with larger lot sizes available for commercial manufacturing runs. This ensures scalability from the laboratory phase to full production cycles.
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Physical Properties
| Melting Point | 235°C |
| Boiling Point | 478.66°C (rough estimate) |
| Density | 1.2764 (rough estimate) |
| Appearance | Pale-yellow crystals. Slowly soluble in 15 parts water; soluble in 9 parts boiling water; soluble in 110 parts alcohol (22C). Solutions are yellow, fluorescent, and stable to boiling. |
| Color | Pale Yellow to Light Yellow |
| Form | Solid |
| Refractive Index | 1.5855 (estimate) |
Safety & Handling
Warning GHS07 GHS09 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H411 Toxic to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P391 Collect spillage. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Other Names
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Chemical Properties
- CAS Number
- 1837-57-6
- EC Number
- 217-408-1
- Mol. Weight
- 343.4
- Category
- Pharmaceutical Intermediates