Overview
2,3,4-Trihydroxybenzaldehyde (CAS 2144-08-3 ), also referenced as 2,3,4-THB, is a polyphenolic aldehyde used across pharmaceutical, cosmetic, and specialty chemical applications.
It functions as an antioxidant, antimicrobial agent, and UV stabilizer in formulated products. In pharmaceutical development, 2,3,4-THB serves as a bioactive intermediate and antioxidant stabilizer.
It is utilized in active ingredient synthesis and finished dosage formulations. Cosmetic formulators incorporate it into skincare products for its UV-protective and preservation properties.
This is particularly useful in formulations targeting oxidative stress or requiring extended shelf stability. Its aldehyde and phenolic character make it relevant in flavor and fragrance compounding.
It contributes to aromatic profiles in specialty applications. Research and fine chemical manufacturers also source it as a building block for synthesizing heterocyclic compounds and novel bioactive molecules.
2,3,4-Trihydroxybenzaldehyde is supplied as a solid crystalline powder. It is available primarily in research and technical grades, with high-purity specifications typically exceeding 98%.
These grades are suited to pharmaceutical intermediates and specialty formulation work. Packaging ranges from small laboratory quantities to bulk orders depending on specific supplier capability.
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Physical Properties
| Melting Point | 230 °C (decomp) |
| Boiling Point | 237.46°C (rough estimate) |
| Density | 1.3725 (rough estimate) |
| Appearance | light brown to beige-brown powder |
| Color | Light brown to beige-brown |
| Form | Powder |
| Water Solubility | 1.541g/L at 25℃ |
| Refractive Index | 1.6400 (estimate) |
| Log P | 1.25 |
Safety & Handling
Warning GHS07 Hazard Statements H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H412 Harmful to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29124990 |
| WGK (Germany) | 2 |
Other Names
Related Products
Chemical Properties
- CAS Number
- 2144-08-3
- EC Number
- 218-404-2
- Mol. Weight
- 154.12
- HS Code
- 29124990
- Category
- Flavors & Fragrances