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Pharmaceutical Intermediates

Hexyl nicotinate

CAS: 23597-82-2

Overview

Hexyl nicotinate (CAS 23597-82-2 ), also known as nicotinic acid hexyl ester, is an ester of nicotinic acid used as a penetration enhancer and carrier in topical formulations.

It promotes localized vasodilation at the skin surface, making it a functional active in cosmetic and pharmaceutical products targeting circulation and warmth response for various applications.

In topical pharmaceutical formulations, it is incorporated into creams and gels designed to produce a warming or flushing sensation, commonly used in muscle rub and sports recovery products.

Cosmetic formulators use it in anti-cellulite creams and body contouring products where visible skin redness and improved microcirculation are desired endpoints for the end user.

It also functions as a carrier and penetration enhancer, improving transdermal delivery of co-formulated actives through the skin barrier to ensure maximum efficacy of the final product.

In pharmaceutical intermediate applications, it serves as a building block for synthesizing nicotinic acid derivatives and related heterocyclic compounds used in advanced chemical synthesis.

The product is supplied as a clear to pale yellow liquid. It is available in technical and cosmetic-grade specifications, with purity levels typically at 98% or higher confirmed by GC analysis.

Packaging options generally range from small laboratory quantities up to bulk drum supply for industrial formulators, ensuring flexible logistics for different manufacturing requirements.

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Physical Properties

Boiling Point140 °C @ Press: 5.0 Torr
Density1.0133 g/cm³ @ Temp: 25 °C
ColorColorless to Almost colorless
Formclear liquid
Water Solubility0.17g/L(32 ºC)
Refractive Index1.4880 to 1.4920
Log P3.510

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29333990

Other Names

nicotinic acid hexyl ester | 3-pyridinecarboxylic acid hexyl ester | Hexyl 3-pyridinecarboxylate | BN07PB44IV | HYGROPLEX HHG | Nicotherm

Related Products

Chemical Properties

CAS Number
23597-82-2
EC Number
245-767-4
Mol. Weight
207.27
HS Code
29333990

Industries

Documentation