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Heterocyclic Compounds

Methyl nicotinate

CAS: 93-60-7

Overview

Methyl nicotinate (CAS 93-60-7 ), also known commercially as Heat Spray in topical applications, is the methyl ester of nicotinic acid used across pharmaceutical synthesis, flavor formulation, and cosmetic actives.

FEMA 3709 status confirms its recognized standing as a flavoring agent in food and beverage applications. In pharmaceutical manufacturing, it serves as a key intermediate in the synthesis of niacin derivatives.

It is utilized in active pharmaceutical ingredients targeting metabolic pathways. Food and beverage formulators use it as a flavoring agent, contributing roasted, meaty, or savory nuance to processed food products.

In personal care and cosmetic formulations, its vasodilatory effect on skin microcirculation makes it a functional active in warming creams, sports massage products, and topical heat-effect preparations.

Fragrance and flavor houses also source it as a building block for heterocyclic aroma compounds in tobacco and savory flavor profiles. Methyl nicotinate is supplied as a white to off-white crystalline solid.

Standard commercial grades include technical, food-grade, and pharmaceutical-grade material meeting USP or BP specifications. This ensures high purity for sensitive industrial and medical applications.

Packaging typically ranges from kilogram quantities up to bulk drum supply depending on grade and application requirements. We ensure consistent quality and supply chain reliability for all global shipments.

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Physical Properties

Melting Point42.5 °C
Boiling Point102-104 °C @ Press: 15 Torr
Density1.2528 (rough estimate)
Flash Point204 °F
Appearancewhite to brownish crystals or crystalline powder
ColorWhite to brownish
Odorat 10.00 % in dipropylene glycol. warm herbal tobacco
FormCrystals or Crystalline Powder
Water SolubilityNEGLIGIBLE
Vapor Pressure0.4 hPa (25 °C)
Refractive Index1.5323 (estimate)
Log P0.68 at 25℃

Safety & Handling

Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation Precautionary Statements P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P321 Specific treatment (see … on this label). P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29333999
WGK (Germany)3

Other Names

Nicotinic acidmethyl ester | Methyl 3-pyridinecarboxylate | Heat spray | 3-pyridinecarboxylic acid methyl ester | 3-(Methoxycarbonyl)pyridine | 3-(Carbomethoxy)pyridine | methyl pyridine-3-carboxylate | Nicometh

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Chemical Properties

CAS Number
93-60-7
EC Number
202-261-8
Mol. Weight
137.14
HS Code
29333999

Industries

Documentation