Overview
Nicotinamide (CAS 98-92-0 ), also known as niacinamide and designated E375 in food applications, is the amide form of vitamin B3 used across pharmaceutical, nutritional, and cosmetic manufacturing.
It functions as an active nutrient, skin-conditioning agent, and formulation stabilizer depending on the end market. In pharmaceutical manufacturing, it is used as an active ingredient in vitamin B3 supplements.
It is found in multivitamin tablets and therapeutic preparations targeting pellagra and metabolic disorders. Food and beverage producers use it as an approved nutrient fortifier in cereals, infant formula, and functional drinks.
In these applications, it restores or enhances B-vitamin content. Cosmetic formulators incorporate niacinamide into serums, moisturizers, and anti-aging creams for its ability to support skin barrier function.
It helps reduce hyperpigmentation and also appears in feed premixes and veterinary nutritional products as a cost-effective B-vitamin source. The material is supplied as a white crystalline powder.
It is available in both food-grade and pharmaceutical-grade specifications. Recognized quality standards include USP , BP , Ph. Eur. , and FCC , ensuring high purity for various industrial uses.
Pharmaceutical grades are subject to stricter purity and heavy metal limits. Bulk supply is standard in 25 kg bags, with smaller packaging available for specialty or cosmetic-grade orders.
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Physical Properties
| Melting Point | 130 °C |
| Boiling Point | 157 °C @ Press: 5 x 10-4 Torr |
| Density | 1.400 g/cm³ @ Temp: 25 °C |
| Flash Point | 182 °C |
| Appearance | White crystalline powder |
| Color | white |
| Odor | Odorless |
| Form | powder |
| Water Solubility | 1000 g/L (20 ºC) |
| Vapor Pressure | 0Pa at 25℃ |
| Refractive Index | 1.4660 (estimate) |
| pH | 6.0-7.5 (50g/l, H2O, 20℃) |
| Log P | -0.38 at 21℃ |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29362990 |
| UN Number | 1230 |
| Packing Group | II |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 98-92-0
- EC Number
- 202-713-4
- Mol. Weight
- 122.12
- HS Code
- 29362990
- Category
- Pharmaceutical Intermediates