Overview
3-Bromoquinoline (CAS 5332-24-1 ) is a halogenated heterocyclic building block used primarily in pharmaceutical synthesis and specialty chemical manufacturing. The bromine substituent at the 3-position makes it a reactive intermediate for cross-coupling reactions.
This functionality enables the efficient construction of more complex quinoline-based structures. In pharmaceutical development, it serves as a key intermediate for synthesizing active pharmaceutical ingredients and drug candidates.
This is particularly relevant where quinoline scaffolds are required for biological activity. Polymer and plastics manufacturers incorporate brominated quinoline derivatives into flame retardant formulations for industrial use.
In these applications, the halogen content contributes to combustion suppression in finished materials. In textile and paper treatment chemistries, it functions as a precursor to preservation and stabilization compounds.
These compounds protect substrates from degradation over time. Research and fine chemical producers also source it for producing ligands, dyes, and specialty reagents where a functionalized quinoline core is the starting point.
3-Bromoquinoline is supplied as a liquid or low-melting solid, typically at purities of 97% or higher for synthetic and research applications. Technical and high-purity grades are available to meet specific requirements.
These grades support pharmaceutical intermediates manufacturing and specialty chemical production. Packaging ranges from small quantities for R&D use to bulk quantities for industrial-scale synthesis programs.
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Physical Properties
| Melting Point | 13.3 °C |
| Boiling Point | 103-105 °C @ Press: 1.5 Torr |
| Density | 1.533 g/mL at 25 °C(lit.) |
| Flash Point | >230 °F |
| Appearance | colorless to light yellow liquid |
| Color | Clear colorless to yellow |
| Form | Liquid |
| Water Solubility | 103mg/L at 25℃ |
| Vapor Pressure | 0.196Pa at 25℃ |
| Refractive Index | n 20/D 1.664(lit.) |
| Log P | 3.03 |
Safety & Handling
Warning GHS07 Hazard Statements H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29334900 |
| UN Number | 2810 |
| Storage Class | 10 - Combustible liquids |
| WGK (Germany) | 3 |
Other Names
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Chemical Properties
- CAS Number
- 5332-24-1
- EC Number
- 226-237-1
- Mol. Weight
- 208.05
- HS Code
- 29334900
- Category
- Heterocyclic Compounds