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Pharmaceutical Intermediates

Glutathione

CAS: 70-18-8

Overview

Glutathione (CAS 70-18-8 ), also known as GSH, is a tripeptide antioxidant produced through fermentation and widely sourced for use across pharmaceutical, food, and cosmetic manufacturing.

It functions as a reducing agent and antioxidant stabilizer, protecting formulations and biological systems from oxidative degradation. In pharmaceutical manufacturing, GSH serves as an active ingredient.

It is used in injectables, oral supplements, and lyophilized drug formulations where oxidative stability is critical. Food and beverage producers incorporate it as an antioxidant to extend shelf life.

In dough systems, it modifies gluten structure to improve processing performance in baked goods. Cosmetic and personal care formulators use it in skin-brightening serums, creams, and topical products.

These products target uneven skin tone through melanin pathway modulation. In biotechnology, it functions as a critical reagent in cell culture media and protein purification processes.

It is particularly useful in refolding disulfide-bonded proteins. This material is supplied as a white to off-white crystalline powder available in pharmaceutical-grade ( USP , BP , Ph. Eur. ) specifications.

It also meets food-grade ( FCC ) requirements to satisfy regulatory standards across different end markets. Reduced glutathione is the predominant commercial form for industrial-scale procurement.

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Physical Properties

Melting Point195 °C
Boiling Point754.5±60.0 °C(Predicted)
Density1.4482 (rough estimate)
AppearanceWhite cryst. powder
ColorWhite
OdorOdorless
Formpowder
Water Solubilitysoluble
Refractive Index-17 ° (C=2, H2O)
pH3 (10g/l, H2O, 20°C)
Log P-1.645 (est)

Safety & Handling

Warning GHS08 Hazard Statements H341 Suspected of causing genetic defects Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P280 Wear protective gloves/protective clothing/eye protection/face protection. P318 IF exposed or concerned, get medical advice. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations.

Trade & Regulatory

HS Code29309070
Storage Class11 - Combustible Solids
WGK (Germany)2

Other Names

Isethion | GSH | Glutinal | Glutide | Glutatiol | Glutathione-SH | Glutathione reduced | Glutathione red

Related Products

Chemical Properties

CAS Number
70-18-8
EC Number
200-725-4
Mol. Weight
307.33
HS Code
29309070

Industries

Documentation