Overview
Lidocaine hydrochloride (CAS 73-78-9 ) is the water-soluble salt form of lidocaine, the benchmark local anesthetic active used across injectable, topical, and dental pharmaceutical formulations.
It is a regulated active pharmaceutical ingredient (API) sourced by formulators, contract manufacturers, and pharmaceutical importers operating under strict pharmacopoeial standards.
In injectable pharmaceuticals, it is formulated into nerve block and epidural anesthetic solutions, requiring high-purity API meeting injectable-grade specifications for safety and efficacy.
Topical formulations, including creams, gels, patches, and sprays, use it as the primary anesthetic active for pain and itch relief in OTC and prescription products across global markets.
Dental cartridge manufacturers incorporate it into lidocaine-epinephrine combination solutions for procedural anesthesia. In cosmetic products, it appears in formulations targeting minor skin discomfort.
Regulatory classification for these applications varies by market and concentration. Lidocaine hydrochloride is supplied as a white crystalline powder for easy integration into various bases.
It is available in USP , BP , and Ph. Eur. grades to meet injectable and oral pharmaceutical requirements, with technical grade available for non-pharmaceutical applications.
Packaging ranges from kilogram quantities for development and compounding use to bulk drums for commercial manufacturing, ensuring scalability for diverse industrial and medical needs.
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Physical Properties
| Melting Point | 77-78 °C |
| Appearance | White to Off-White Solid |
| Color | White to off-white |
| Form | Solid |
| Water Solubility | Water : ≥ 36 mg/mL (132.94 mM) |
| Log P | 2.359 (est) |
Safety & Handling
Danger GHS06 GHS07 GHS08 Hazard Statements H301 Toxic if swallowed H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled H335 May cause respiratory irritation H412 Harmful to aquatic life with long lasting effects Precautionary Statements P233 Keep container tightly closed. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P284 In case of inadequate ventilation wear respiratory protection. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P403 Store in a well-ventilated place. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P316 Get emergency medical help immediately. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P342+P316 Get emergency medical help immediately. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Other Names
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Chemical Properties
- CAS Number
- 73-78-9
- EC Number
- 200-803-8
- Mol. Weight
- 270.80
- Category
- Pharmaceutical Intermediates