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Pharmaceutical Intermediates

Tris(2-butoxyethyl) phosphate

CAS: 78-51-3

Overview

Tris(2-butoxyethyl) phosphate (CAS 78-51-3 ), commonly identified in industry as TBEP, is an organophosphate ester used as both a plasticizer and flame retardant across a broad range of industrial formulations.

Its dual functionality allows formulators to reduce flammability while maintaining or improving substrate flexibility. This combination drives its specification in demanding end-use applications across various sectors.

In coatings, adhesives, and sealants, TBEP functions as a reactive plasticizer that improves flexibility and film formation. It simultaneously contributes flame retardancy to the cured system for enhanced safety.

Floor polish and wax formulations rely on TBEP to control leveling and gloss. In these applications, it acts as a coalescing agent for polymer emulsions to ensure a smooth and consistent finish.

Textile and leather finishes incorporate it to impart softness and reduce ignition risk in treated fabrics and hides. This makes it a vital component for high-performance materials in the upholstery industry.

In electronics and printed circuit board laminates, TBEP is specified where a non-halogenated flame retardant is required. It meets fire safety standards without compromising the overall processability of the components.

TBEP is supplied as a clear liquid, typically in drum and IBC quantities suited to industrial procurement volumes. It is available in technical grade, which is the standard specification for most applications.

Purity specifications and low-acid-value grades are available for formulators with tighter quality requirements. These options ensure compatibility with sensitive chemical systems and specialized manufacturing needs.

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Physical Properties

Melting Point-70 °C
Boiling Point215-228 °C @ Press: 4 Torr
Density1.020 g/cm³ @ Temp: 20 °C
Flash Point>230 °F
AppearanceSlightly yellow, oily liquid. Insoluble or limited solubility in glycerol, glycols, and certain amines; soluble in most organic liquids. Combustible.
ColorClear colorless to very slightly yellow
FormLiquid
Water SolubilitySoluble
Vapor Pressure0.03 mm Hg ( 150 °C)
Refractive Indexn 20/D 1.438(lit.)
Log P3.75 at 20℃

Safety & Handling

Warning GHS07 Hazard Statements H312 Harmful in contact with skin H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H336 May cause drowsiness or dizziness H402 Harmful to aquatic life H412 Harmful to aquatic life with long lasting effects Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29199000
WGK (Germany)1

Other Names

Tri(2-butoxyethyl) phosphate | TBEP | Phosphoric acidtris(2-butoxyethyl) ester | Phosphoric acidtri-(2-butoxyethyl) ester | Tributoxyethyl phosphate | Phosflex T-bep | Tris(butoxyethyl) phosphate | Tributyl cellosolve phosphate

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