Overview
Tetrahydrofuran (CAS 109-99-9 ), commonly known as THF or oxolane, is a cyclic ether solvent with exceptional miscibility across both polar and non-polar systems. It dissolves a broad range of polymers, resins, and active compounds.
This versatile solvent handles materials that resist other common liquids, making it a go-to choice for demanding formulation and synthesis work. In pharmaceutical manufacturing, it is used as a reaction solvent and extraction medium.
Its ability to solvate organolithium and Grignard reagents is critical to process chemistry during API synthesis. PVC adhesives and coatings rely on this chemical as the primary solvent, enabling strong substrate bonding in pipe fittings.
It is also utilized in footwear and industrial laminates. It functions as a polymerization solvent in the production of polytetramethylene ether glycol (PTMEG), a key intermediate for spandex fibers and polyurethane elastomers.
In analytical and QC laboratories, it serves as a standard HPLC mobile phase component for separating polymers and pharmaceutical compounds. The product is supplied as a clear liquid in drums, IBCs, and bulk tanker quantities.
Anhydrous and stabilized grades are the most common commercial forms, with stabilizer-free variants available for sensitive synthesis applications. Technical and reagent-grade specifications are standard for industrial use.
HPLC-grade is available for laboratory and analytical procurement. Our material meets rigorous industry requirements to ensure consistent performance across all manufacturing and research applications.
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Physical Properties
| Melting Point | -108.3 °C |
| Boiling Point | 65 °C @ Press: 760 Torr |
| Density | 0.8892 g/cm³ @ Temp: 20 °C |
| Flash Point | >230 °F |
| Appearance | Tetrahydrofuran is a colorless liquid. Ethereal odor. The Odor Threshold is listed @ 3.8 (3M), 20-50 ppm, and 31 ppm. |
| Color | <10(APHA) |
| Odor | Ethereal, detectable at 2 to 50 ppm |
| Form | Liquid |
| Water Solubility | miscible |
| Vapor Pressure | <0.01 mm Hg ( 25 °C) |
| Refractive Index | n 20/D 1.465 |
| pH | 7-8 (200g/l, H2O, 20℃) |
| Log P | 0.45 at 25℃ |
Safety & Handling
Danger GHS02 GHS07 GHS08 Hazard Statements H225 Highly Flammable liquid and vapor H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H336 May cause drowsiness or dizziness H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child H370 Causes damage to organs H371 May cause damage to organs H372 Causes damage to organs through prolonged or repeated exposure Precautionary Statements P203 Obtain, consult and follow expert instructions for use. P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/…] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P318 IF exposed or concerned, get medical advice. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P308+P316 Get emergency medical help immediately. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P370+P378 Use … for extinction. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P403+P235 Store in a well-ventilated place. Keep cool. P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29321100 |
| UN Number | 2924 |
| ADR Class | 3 |
| Packing Group | II |
| Storage Class | 3 - Flammable liquids |
| WGK (Germany) | 1 |
Other Names
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Chemical Properties
- CAS Number
- 109-99-9
- EC Number
- 203-726-8
- Mol. Weight
- 72.11
- HS Code
- 29321100
- Category
- Catalysts & Catalyst Precursors