Overview
Disodium EDTA dihydrate (CAS 6381-92-6 ) is the dihydrate form of the disodium salt of ethylenediaminetetraacetic acid, commonly sourced under the abbreviation EDTA disodium. It functions as a chelating and sequestering agent.
By binding metal ions, it prevents oxidation, discoloration, and microbial activity across a broad range of industrial and consumer product applications. In personal care and cosmetics, it stabilizes formulations by deactivating trace metals.
This prevents the degradation of preservatives or the development of rancidity in creams, shampoos, and lotions. Food and beverage manufacturers use it to prevent metal-catalyzed oxidation in canned goods and dressings.
It is particularly effective in seafood products where color and shelf life are critical quality parameters. Water treatment operations deploy it to sequester calcium and magnesium ions, controlling scale formation in industrial systems.
In pharmaceutical manufacturing, it enhances preservative efficacy in ophthalmic and injectable formulations. It achieves this by chelating metal cofactors that support microbial growth in sensitive medical products.
Disodium EDTA dihydrate is supplied as a white crystalline powder. Standard grades include food-grade ( FCC ), USP , BP , and Ph. Eur. , supporting procurement across various highly regulated industries.
Technical grade is also available for industrial applications such as textile processing and leather treatment. It is widely used in water treatment where specific pharmacopeial certification is not strictly required.
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Physical Properties
| Melting Point | 250 °C (dec.)(lit.) |
| Boiling Point | >100 °C |
| Density | 1.01 g/mL at 25 °C |
| Flash Point | >100°C |
| Appearance | White crystalline powder |
| Color | ≤5 (0.5 M)(APHA) |
| Odor | Odorless |
| Form | crystalline |
| Water Solubility | soluble |
| Refractive Index | n 20/D 1.363 |
| pH | 4.0-5.5 (25℃, 0.1M in H2O) |
Safety & Handling
Warning GHS07 GHS08 Hazard Statements H302 Harmful if swallowed H312 Harmful in contact with skin H315 Causes skin irritation H319 Causes serious eye irritation H332 Harmful if inhaled H335 May cause respiratory irritation H373 May causes damage to organs through prolonged or repeated exposure H412 Harmful to aquatic life with long lasting effects Precautionary Statements P260 Do not breathe dust/fume/gas/mist/vapours/spray. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P271 Use only outdoors or in a well-ventilated area. P273 Avoid release to the environment. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P330 Rinse mouth. P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P301+P317 Get emergency medical help. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Trade & Regulatory
| HS Code | 29224995 |
| Storage Class | 11 - Combustible Solids |
| WGK (Germany) | 2 |
Other Names
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Chemical Properties
- CAS Number
- 6381-92-6
- EC Number
- 613-386-6
- Mol. Weight
- 372.24
- HS Code
- 29224995
- Category
- Chelating Agents