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Pharmaceutical Intermediates

Isobutylparaben

CAS: 4247-02-3

Overview

Isobutylparaben (CAS 4247-02-3 ), also known as isobutyl 4-hydroxybenzoate, is a paraben-series preservative used across food, pharmaceutical, and cosmetic manufacturing.

It inhibits microbial growth in finished formulations, extending product shelf life across a broad range of applications. In cosmetics and personal care, it functions as a preservative.

It is used in creams, lotions, and emulsions where longer oil-phase compatibility is required compared to shorter-chain parabens. Pharmaceutical manufacturers incorporate it into topical preparations.

It is also used in oral suspensions and semi-solid dosage forms to prevent microbial contamination during storage. Food-grade applications include use as an antimicrobial agent.

This applies to certain processed food products where regulatory frameworks permit paraben use. It also appears as an intermediate in the synthesis of more complex paraben esters.

Isobutylparaben is supplied as a white crystalline powder. Standard commercial grades include food-grade and pharmaceutical-grade material, with the latter typically conforming to USP specifications.

The material may also conform to Ph. Eur. standards. Packaging is available in kilogram-scale quantities for laboratory and formulation use, as well as larger bulk formats.

These bulk formats are designed for industrial production. The product ensures high stability and efficacy across various pH levels in diverse manufacturing environments.

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Physical Properties

Melting Point74-77 °C
Boiling Point302.3±15.0 °C(Predicted)
Density1.105±0.06 g/cm3(Predicted)
ColorWhite
Formneat
Water SolubilityInsoluble in water.
Vapor Pressure0.001Pa at 20℃
Log P3.43 at 23℃

Safety & Handling

Danger GHS05 GHS07 Hazard Statements H315 Causes skin irritation H318 Causes serious eye damage Precautionary Statements P264 Wash … thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P321 Specific treatment (see … on this label). P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P332+P317 Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29182900
UN Number3077
ADR Class9
Packing GroupIII
Storage Class13 - Non Combustible Solids
WGK (Germany)2

Other Names

Isobutyl 4-hydroxybenzoate | Isobutyl p-hydroxybenzoate | Isobutyl parahydroxybenzoate | Benzoic acid4-hydroxy-2-methylpropyl ester | Benzoic acidp-hydroxy-isobutyl ester | 2-Methylpropyl p-hydroxybenzoate

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Chemical Properties

CAS Number
4247-02-3
EC Number
224-208-8
Mol. Weight
194.23
HS Code
29182900

Industries

Documentation