Back to Catalog
Pharmaceutical Intermediates

Diethyl phosphite

CAS: 762-04-9

Overview

Diethyl phosphite ( CAS 762-04-9 ), also referred to commercially as diethyl phosphonate or DEP, is a reactive organophosphorus compound used as a chemical intermediate and functional additive across multiple industrial sectors.

It acts as a building block for synthesizing phosphorus-containing compounds and delivers antioxidant, stabilizing, and lubrication functions in finished formulations. In lubricant and metalworking fluid formulations, DEP functions as an extreme-pressure additive.

It serves as an antiwear agent, reducing metal surface degradation under high-load conditions. Pharmaceutical manufacturers use it as a key intermediate in the synthesis of active pharmaceutical ingredients, particularly antiviral and antiparasitic compounds.

In agrochemical production, it serves as a precursor in the manufacture of organophosphate pesticides and herbicides. Polymer and plastics processors incorporate DEP as a flame retardant additive and stabilizer.

This helps to meet flammability and thermal performance requirements in end products. Diethyl phosphite is supplied as a clear, colorless to pale yellow liquid in drum and IBC quantities, with bulk tanker supply available.

Technical grade is the standard commercial offering, with purity levels typically at 98% or higher. Pharmaceutical-intermediate-grade material with controlled impurity profiles is available from select manufacturers.

This material is designed to support API synthesis qualification requirements. The product is handled according to strict industrial safety protocols to ensure consistent quality and performance across all applications.

Contact us for supply of Diethyl phosphite

Physical Properties

Melting Point<25 °C
Boiling Point50-51 °C @ Press: 2 Torr
Density1.072 g/cm³
Flash Point180 °F
Appearancecolourless liquid
ColorColorless
FormLiquid
Water Solubilitymiscible (hydrolysis)
Vapor Pressure7hPa at 20℃
Refractive Indexn 20/D 1.407(lit.)
Log P-0.15

Safety & Handling

Danger GHS05 GHS07 Hazard Statements H315 Causes skin irritation H317 May cause an allergic skin reaction H318 Causes serious eye damage H319 Causes serious eye irritation H335 May cause respiratory irritation Precautionary Statements P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P264 Wash … thoroughly after handling. P271 Use only outdoors or in a well-ventilated area. P272 Contaminated work clothing should not be allowed out of the workplace. P280 Wear protective gloves/protective clothing/eye protection/face protection. P317 Get emergency medical help. P319 Get medical advice/attention if you feel unwell. P321 Specific treatment (see … on this label). P405 Store locked up. P501 Dispose of contents/container in accordance with local regulations. P264+P265 Wash … thoroughly after handling. P302+P352 IF ON SKIN: Wash with plenty of water. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P332+P317 Get emergency medical help. P333+P317 Get emergency medical help. P337+P317 If eye irritation persists: Get medical advice/attention. Get emergency medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P305+P354+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Trade & Regulatory

HS Code29209014
Storage Class10 - Combustible liquids
WGK (Germany)1

Other Names

phosphorous acid diethyl ester | diethyl phosphonate | diethyl hydrogenphosphite | Phosphonic acid diethyl ester | Diethoxyphosphine oxide | Diethyl acid phosphite | Hydrogen diethyl phosphite | OO-Diethyl phosphonate | DEP

Related Products

Chemical Properties

CAS Number
762-04-9
EC Number
212-091-6
Mol. Weight
137.09
HS Code
29209014

Industries

Documentation